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Address correspondence to: Jens Titze, Division of Clinical Pharmacology, Vanderbilt University Medical Center, 2213 Garland Avenue, P435F MRBIV, Nashville, Tennessee 37232, USA. Any decrease or increase in the subject’s dietary salt intake resulted in a parallel decrease or increase in his urine osmolyte excretion.

in: JCI | Pub Med | Google Scholar Department of Pediatrics, University Clinic Erlangen, Erlangen, Germany. We show the relationship between the salt intake phase, osmolyte excretion, and free water clearance (FWC) in the same representative subject (Figure 2A).

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Address correspondence to: Jens Titze, Division of Clinical Pharmacology, Vanderbilt University Medical Center, 2213 Garland Avenue, P435F MRBIV, Nashville, Tennessee 37232, USA. We therefore next tested the hypothesis that the salt-driven increase in urine osmolyte excretion was coupled with enhanced free water reabsorption. A 6-g/d increase in salt intake did not significantly increase the urine volume (Figure 1, D and E). Address correspondence to: Jens Titze, Division of Clinical Pharmacology, Vanderbilt University Medical Center, 2213 Garland Avenue, P435F MRBIV, Nashville, Tennessee 37232, USA. Water intake in the lowest (first) tertile of UNa V was 237 ± 27 ml/d higher than in the highest (third) tertile of UNa V (Figure 1C). Address correspondence to: Jens Titze, Division of Clinical Pharmacology, Vanderbilt University Medical Center, 2213 Garland Avenue, P435F MRBIV, Nashville, Tennessee 37232, USA. We therefore additionally classified UNa V values into 3 tertiles of low, medium, and high UNa V levels to test for the effect of renal Na elimination on water balance.

in: JCI | Pub Med | Google Scholar Department of Pediatrics, University Clinic Erlangen, Erlangen, Germany. excretion led to a lagged elimination of dietary salt, resulting in periodically low and high levels of salt excretion at each dietary salt intake phase, which may have masked the diuretic effect of elevated salt intake. (E) Quantification of the changes in urine osmolyte excretion per salt intake phase or per 24-hour UNa V tertile.



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