Updating the concept of prebiotics Erotic mobile chat rooms


16-Jun-2020 19:22

updating the concept of prebiotics-33

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Although created for IBD, this conceptual framework is relevant to other complex disorders such as IBS, colorectal and gastric cancers, non-alcoholic steatohepatitis and autoimmune diseases.In these diseases, interactions between genetic, microbial and environmental influences lead to heterogeneous phenotypes in patient subsets that are uniquely responsive to specific microbial manipulations.Probiotics are derived from traditional fermented foods, from beneficial commensals or from the environment.They act through diverse mechanisms affecting the composition or function of the commensal microbiota and by altering host epithelial and immunological responses.This review provides an update on probiotic effects on treatment or prevention of important gastroenterological conditions: irritable bowel syndrome (IBS), infectious diarrhoea including nosocomial infections, inflammatory bowel disease (IBD), necrotising enterocolitis (NEC), as well as cancer and cancer therapy.We also address the impact of probiotics on indicators of health, as measured through reduction in the incidence of common infectious diseases and risk of allergy, improvement in bowel function, and modulation of immune function.However, the results of studies evaluating the preventive effect of probiotics on nosocomial infections have been mixed.Some show benefit,38 GG was effective in reducing nosocomial gastrointestinal and respiratory tract illnesses in over 2000 immunocompetent children ≥1 year of age without underlying illnesses who were suddenly hospitalised for reasons unrelated to gastrointestinal or respiratory tract problems.39 Although probiotics show promise in reducing nosocomial infections among some populations, they are not recommended for critically ill hospitalised patients at this time.46 Nissle in inducing and maintaining remission of disease activity in mild to moderately severe ulcerative colitis.50–53 Primary prevention of pouchitis and reducing the likelihood of relapse after successful antibiotic treatment has also been successful, receiving an ‘A’ recommendation by Floch 32 Possible reasons for the current disparity between therapeutic potential and actual clinical outcomes of probiotic use in IBD are summarised in table 1, which includes proposed strategies to enhance therapeutic outcomes.

Nosocomial infections remain a major healthcare concern, with estimated yearly direct medical costs in the USA of US–45 billion,37 pointing to the need for a preventive approach.

(B) Hypothesised future uses for probiotics in modifying the composition or activities of the microbiota for improved health.



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