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The calcium dependency of the depolarization-induced histamine release has also been reported for hypothalamic slices 1 * 21 . Aaron* u) .hoptramide and (R)a-mcihvl- hivnjninc tn ar hruf histamine JH r and H^rccop- The effect of thioperamide tested nn the e AMP accumulation elicited by histamine, a rc- known to involve the itimuiation of both H r ;ind H .-receptor* in slices from guinea-pig hipptvampus. 30 and 0.1 m M, did not modify *ignificantl y the concenlrdtion-response for hi.uai» : -u (f,g. Tho r^ulu are expressed is ptrccniugc a/ the manwu) response io hjctaminc. 0 r t S)a-derivative wai completely abolished by the addition of the H 3 -recepior anugoni.u. The effects of the two euantiomeri of Q-methylhistaminc were concentraiion-depen- dem in the absence a* well as in the presence of dimaprit. The agonist behaved as a partial agonist on this model, as wejl a mcthy Lhis:arnine wis a subsiraie (Hou&h et a J.. Although this property ha* allowed us to develop a radioeruymatic assay for the drug, its K„ »s 27 /i M f Hough et ni„ 19R1), a concentration Time after (a;* -uethylhist amis£ (nnsj F'.g. Eff ec , of (R)tf.rncihyih Uiamine hi.starainc and N*. … continue reading »


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