Aymptomatic hsv 2 dating
Finally, what should we tell our patients regarding asymptomatic shedding and the risk of transmission?
Patents with genital herpes should be counseled that simply avoiding sexual contact when lesions are present is not adequate for prevention of transmission and that asymptomatic shedding is frequent and is the most common mechanism of transmission to sex partners.
Patients can also be counseled that, although nothing short of abstinence can provide complete protection, the risk of transmission can be significantly reduced by both suppressive antiviral therapy and regular use of condoms. receives no direct salary support for these activities.
Potential conflicts of interest: The University of New Mexico Department of Internal Medicine has received grant funding from Astellas Pharma, which is developing an anti-viral drug for herpes simplex virus infections, and from the National Institutes of Health, which is evaluating the efficacy of an HSV vaccine developed by Glaxo Smith Kline.
The frequency of asymptomatic shedding was clarified in a series of prospective studies based on detection of viral shedding by polymerase chain reaction (PCR) amplification of viral DNA, which is far more sensitive than virus culture .
In these studies, asymptomatic shedding from anogenital sites was documented in 80%–90% of seropositive men and women, was present on ~20% of days with daily sampling, and was present at even higher frequency during the first 3 months after acquisition of first-episode genital herpes [12–18].
, the previous PCR-based shedding studies [12–16], and the once daily valacyclovir transmission study  is that there is now enough data to consider PCR-based measurement of asymptomatic shedding rates as a surrogate marker for transmission risk.
Although acyclovir 400 mg by mouth twice daily did not decrease the incidence of HIV infection among women in Tanzania, adherence based on pill counts was suboptimal, and there was no significant decrease in asymptomatic genital shedding of HSV-2 among the acyclovir recipients .
Transmission occurred in 14 (9.7%) of the couples, including 13 in which diaries were maintained during the period when transmission occurred.